Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof

一种含中药抗菌成分黄连素的海藻酸钠纳米纤维医用敷料及其制备方法

Abstract

The invention discloses a sodium alginate nanofiber surgical dressing containing a traditional Chinese medicine antibiotic component berberine. The sodium alginate nanofiber surgical dressing is prepared by sodium alginate, polyving akohol and the traditional Chinese medicine antibiotic component berberine by an electrostatic spinning method; wherein the proportion of a sodium alginate solution to a polyving akohol solution in an electrostatic spinning solution is 4:6-5:5, and content of berberine accounts for 3-6wt% of that of sodium alginate and polyving akohol. Due to no addition of harmful substances such as a strong non-polar solution during a preparation method of the surgical dressing, the used berberine is safe and harmless, bacteria cannot generate drug resistance, the sodium alginate nanofiber surgical dressing containing the traditional Chinese medicine antibiotic component berberine has the advantages of safe and reliable usage and high efficiency bacterinertness, and has escherichia coli antibacterial rate being 92.9-97.1%.
本发明公开了一种含中药抗菌成分黄连素的海藻酸钠纳米纤维医用敷料。该医用敷料由海藻酸钠、聚乙烯醇和中药抗菌成分黄连素由静电纺丝手段制备而成,其中静电纺丝液中海藻酸钠溶液和聚乙烯醇溶液的比例为4:6-5:5,黄连素的含量为海藻酸钠、聚乙烯醇质量的3wt%-6wt%。由于该医用敷料制备过程中强无极性溶剂等有害性物质的添加,且使用的抗菌成分黄连素安全无害、不会使细菌产生耐药性,因此本发明制备的含中药抗菌成分黄连素的海藻酸钠纳米纤维医用敷料,不仅使用时安全可靠,还具有高效抗菌性,其对大肠杆菌的抑菌率达92.9%-97.1%。

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